iSync informed me that it would have to disable a few conduits. No sweat. I wasn't going to need those -- and iSync was going to move them to the iSync Disabled Conduits folder if I needed them again.
I fired up Mark/Space and selected my iSync conduit.
So far, so good. Hit the sync button on my cradle and it began the process. If everything works out ok, my contacts and calendars will now be updated in iCal and Address Book. I'm counting on Missing Sync along with iSync to use the data in my Treo to fill those desktop applications. The sync process concluded without any problems.